It’s “HARDUP”, which stands for the following: for: Medscape.Įleanor Lederer, MD, FASN Professor of Medicine, Chief, Nephrology Division, Director, Nephrology Training Program, Director, Metabolic Stone Clinic, Kidney Disease Program, University of Louisville School of Medicine Consulting Staff, Louisville Veterans Affairs HospitalĮleanor Lederer, MD, FASN is a member of the following medical societies: American Association for the Advancement of Science, American Society for Bone and Mineral Research, American Society of Nephrology, American Society of Transplantation, International Society of Nephrology, Kentucky Medical Association, National Kidney Foundationĭisclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: American Society of NephrologyReceived income in an amount equal to or greater than $250 from: Healthcare Quality Strategies, Inc.As I’ve mentioned previously on this blog, the “MUDPALES” mnemonic for anion gap metabolic acidosis is one of the most successful medical mnemonic’s of all time.Ī less successful (and admittedly less useful) mnemonic exists for non-anion gap metabolic acidoses (NAGMA), which I learned as a resident. 1-10.įrancisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy Editor-in-Chief, Medscape Drug Referenceĭisclosure: Received salary from Medscape for employment. Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning. Zakharov S, Pelclova D, Navratil T, Belacek J, Latta J, Pisar M, et al. Lactic Acidosis: Current Treatments and Future Directions. A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate. Management of the Metabolic Acidosis of Chronic Kidney Disease. Should chronic metabolic acidosis be treated in older people with chronic kidney disease?.
Effects of oral sodium bicarbonate in patients with CKD. 2015 Oct 15.Ībramowitz MK, Melamed ML, Bauer C, Raff AC, Hostetter TH. Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study. Kendrick J, Shah P, Andrews E, You Z, Nowak K, Pasch A, et al. Correction of metabolic acidosis improves muscle mass and renal function in chronic kidney disease stages 3 and 4: a randomized controlled trial. 29 (5):1411-1425.ĭubey AK, Sahoo J, Vairappan B, Haridasan S, Parameswaran S, Priyamvada PS. Mechanism of Hyperkalemia-Induced Metabolic Acidosis. Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, et al. Correction of metabolic acidosis with potassium citrate in renal transplant patients and its effect on bone quality. Starke A, Corsenca A, Kohler T, Knubben J, Kraenzlin M, Uebelhart D, et al. Molecular pathophysiology of renal tubular acidosis. Pereira PC, Miranda DM, Oliveira EA, Silva AC. Urinary acidification assessed by simultaneous furosemide and fludrocortisone treatment: an alternative to ammonium chloride. Walsh SB, Shirley DG, Wrong OM, Unwin RJ. Acid-base variables in patients with acute kidney injury requiring peritoneal dialysis in the pediatric cardiac care unit. Differences in acid-base behavior between intensive care unit survivors and nonsurvivors using both a physicochemical and a standard base excess approach: a prospective, observational study. Profound Metabolic Acidosis due to Metformin Intoxication Requiring Dialysis. Emergent Hemodialysis Followed by Continuous Renal Replacement Therapy: A Management Challenge in a Patient With Life-Threatening Metabolic Acidosis of Multifactorial Etiology. Yousaf A, Malik B, Abdelazeem B, Kunadi A. GOLD MARK: an anion gap mnemonic for the 21st century. Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle. Metformin-associated lactic acidosis: Current perspectives on causes and risk.
1-11.ĭeFronzo R, Fleming GA, Chen K, Bicsak TA. Chronic Metabolic Acidosis in Chronic Kidney Disease. The frequency and severity of metabolic acidosis related to topiramate. Türe H, Keskin Ö, Çakır Ü, Aykut Bingöl C, Türe U. Non-Anion Gap Metabolic Acidosis: A Clinical Approach to Evaluation. Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study. Noritomi DT, Soriano FG, Kellum JA, et al.
Clinical utility of anion gap in deciphering acid-base disorders. Imaging Studies and Electrocardiographyīurger MK, Schaller DJ.Urine-Blood PaCO2 Gradient Following HCO3- Loading.Plasma Renin Activity, Plasma Aldosterone levels, and FEHCO3.
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